Hepatic biotransformation of MLN8054 was analyzed in vitro applying human liver S9 fractions (Information on file, Millennium). Glucuronidation in the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant mechanism of biotransformation, Hydroxylation in the azepine moiety of MLN8054 was the key stage one biotransformation pathway
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As an example, to change the dose of Compound A used for a mouse (20 mg/kg) to some dose determined by the BSA for your rat, multiply 20 mg/kg through the Km variable for the mouse and then divide by the Km element for your rat. This calculation ends in a rat equal dose for Compound A of ten mg/kg.Be sure to find the appropriate solvent to arrange